Abstract
AbstractGymnotus carapo, an electric knife fish, produces a continuous spontaneous discharge, the rate of which is subject to modulation, when the fish is disturbed. Free swimming knife fish of this species were subjected to the action of chlorpromazine and methylphenidate, while the discharge was detected by electrodes in the corners of the aquarium and recorded on magnetic tape. Methylphenidate increased and chlorpromazine decreased the frequency. The log dose response curves for both compounds presented a straight line relationship. The usefulness of the technique for bioassay of compounds acting on the central nervous system is discussed briefly.
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