Abstract
Precise deposition of nanofibers is still an important issue in the applications of electrospinning (e-spinning), especially in rapid hemostasis of organs such as the liver, lung, and kidney. In this study, we propose an electric field-modified e-spinning technique with a metal cone attached to the spinning nozzle to realize controllable precise deposition of fibers. The deposition range of the e-spun fibers is tunable by changing the size of the metal cone, and the mechanism is attributed the focused electric field verified by theoretical simulations. This electric field-modified e-spinning method was further used to in situ precisely deposit medical glue N-octyl-2-cyanoacrylate (NOCA) fibers onto the resection site of rat liver to realize rapid hemostasis within 10 s. Postoperative pathological results indicate that less inflammatory response and tissue adhesion are observed in this electric field-modified e-spinning group compared with that of traditional airflow-assisted group. This technique combined with our designed handheld e-spinning device could be used in emergency medical treatment, clinics, field survival, and home care for its portability and precise deposition characteristics.
Highlights
Liver resection is an effective way to treat cancers in the liver [1]
Postoperative pathological results indicate that less inflammatory response and tissue adhesion are observed in this electric field-modified e-spinning group compared with those in the traditional airflow-assisted group. This technique combined with our designed handheld e-spinning device could be used in emergency medical treatment, clinics, field survival, and home care for its portability and precise deposition characteristics
In summary, we propose an electric field-modified e-spinning technique with a metal cone attached to the spinning nozzle to realize controllable precise deposition of fibers
Summary
Liver resection is an effective way to treat cancers in the liver [1]. Heavy bleeding usually occurs in liver resection due to the abundant blood vessel in this special site [2]. Failure to stop bleeding timely can lead to serious organ failure which could even threaten the human life [3]. Current methods to stop bleeding are mostly focused on mechanical methods like suture and ligation, thermal methods like electrocautery [4], and using hemostatic method agents like fibrin sealants [5, 6], gelatin matrix [7], and chitosan hydrogel adhesive [8]. All of them have obvious advantages and limitations. Suture is the most effective way to stop bleeding, but it needs a timely and meticulous process; otherwise, it causes long-term ischemia [9]. Thermal methods can damage the local tissues
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