Abstract
Elastosis perforans serpiginosa in a patient with Down syndrome treated with imiquimod 5% cream
Highlights
Elastosis Perforans Serpiginosa(EPS) is a rare skin disease with unknown etiology belonging to the group of perforating dermatoses.[1]
EPS is characterized by grouped hyperkeratotic papules and plaques with central heeling, often symmetrically located on upper and lower extremities, trunk and face
The patient had no adverse effects. This case report describes a patient with Down syndrome with EPS successfully treated with imiquimod 5% cream
Summary
Elastosis Perforans Serpiginosa(EPS) is a rare skin disease with unknown etiology belonging to the group of perforating dermatoses.[1] The disease is associated with systemic disorders like Down syndrome, EhlersDanlos syndrome, Marfan syndrome[2,3] and it exists in a drug-induced form by pencillamine.[4] EPS is characterized by increased elastic tissue in papillary dermis, inflammation and transepidermal elimination of abnormal elastic fibers.[5] This response is more generalised and prolonged in cases associated with Down syndrome. EPS is characterized by grouped hyperkeratotic papules and plaques with central heeling, often symmetrically located on upper and lower extremities, trunk and face. Imiquimod therapy has been introduced to treat EPS.[8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
