Abstract

Preface. Elastic Filaments of the Cell. Connecting Filaments: A Historical Prospective K. Trombitas. Connectin: From Regular to Giant Sizes of Sarcomeres K. Maruyama, S. Kimura. Molecular Tools for the Study of Titin's Differential Expression T. Centner, et al. Sequence and Mechanical Implications of Titin's PEVK Region M.L. Greaser, et al. Probing the Functional Roles of Titin Ligands in Cardiac Myofibril Assembly and Maintenance A.S. McElhinny, et al. Assembly of Myofibrils in Cardiac Muscle Cells J.W. Sanger, et al. General Discussion I. Molecular Mechanism of Elasticity. Mechanical Manipulation of Single Titin Molecules with Laser Tweezers M.S.Z. Kellermayer, et al. Unfolding Forces of Titin and Fibronectin Domains Directly Measured by AFM M. Rief, et al. Computer Modeling of Force-Induced Titin Domain Unfolding H. Lu, et al. Extensibility in the Titin Molecule and its Relation to Muscle Elasticity L. Tskhovrebova, J. Trinick. Titin Elasticity in the Context of the Sarcomere: Force and Extensibility Measurements on Single Myofibrils W.A. Linke. Titin-Like Proteins. Links in the Chain: The Contribution of Kettin to the Elasticity of Insect Muscles B. Bullard, et al. Titin as a Chromosomal Protein C. Machado, D.J. Andrew. Role of the Elastic protein Projectin in Stretch Activation and Work Output of Drosophila Flight Muscles J.O. Vigoreaux, et al. Drosophila Projectin: A Look at Protein Structure and Sarcomeric Assembly A. Ayme-Southgate, et al. Role of Titin in Nonmuscle and Smooth Muscle Cells T.C.S. Keller III, et al. Functional Role of Elastic Filaments. Mechanical Properties of Titin Isoforms H. Granzier, et al. Intact Connecting Filaments Change Length in 2.3-nm Quanta F. Blyakhman, et al. Titin-Thin Filament Interaction and Potential Role in Muscle Function J.-P. Jin. Is Titin the Length Sensor in Cardiac Muscle? Physiological and Physiopathological Perspectives J.-Y. Le Guennec, et al. Ca2+-Dependence of Passive Properties of Cardiac Sarcomeres B.D. Stuyvers, et al. Possible Contribution of Titin Filaments to the Compliant Series Elastic Component in Horseshoe Crab Skeletal Muscle Fibers H. Sugi, et al. Skeletal Muscle-Specific Calpain, p94, and Connectin/Titin: Their Physiological Functions and Relationship to Limb-Girdle Muscular Dystrophy Type 2A H. Sorimachi, et al. General Discussion II. From Connecting Filaments to Co-Expression of Titin Isoforms K. Trombitas, et al. Index.

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