Elastic energy of tilt and bending of fluid membranes

Abstract

Tilt of hydrocarbon chains of lipid molecules with respect to membrane plane is commonly considered to characterize the internal structure of a membrane in the crystalline state. However, membranes in the liquid state can also exhibit tilt resulting from packing constraints imposed on the lipid molecules in diverse biologically relevant structures such as intermediates of membrane fusion, pores in lipid bilayers and others. We analyze the energetics of tilt in liquid membranes and its coupling with membrane bending. We consider three contributions to the elastic energy: constant tilt, variation of tilt along the membrane surface and membrane bending. The major assumption of the model is that the core of a liquid membrane has the common properties of an elastic continuum. We show that the variation of tilt and membrane bending are additive and that their energy contributions are determined by the same elastic coefficient: the Helfrich bending modulus, the modulus of Gaussian curvature and the spontaneous curvature known from previous studies of pure bending. The energy of a combined deformation of bending and varying tilt is determined by an effective tensor accounting for the two factors. In contrast, the deformation of constant tilt does not couple with bending and its contribution to the elastic energy is determined by an independent elastic constant. While accurate determination of this constant requires additional measurements, we estimate its value using a simplified approach. We discuss the relationships between the obtained elastic Hamiltonian of a membrane and the previous models of membrane elasticity.