Elastase 長期使用時の循環動態, 特に非観血的動脈硬化度指標の変化について

Abstract

We observed the hemodynamic and antisclerotic effects of Elastase (10800 E. S. units daily, orally) in 16 patients having arteriosclerotic disease for a period of 6 to 12 months.As the indices of arteriosclerosis, we used the pulse wave velocity and the volume elasticity in the Windkessel system, and got those indices and other hemodynamic parameters by Wezler's and Blumberger-Holldack's methods non-invasively and mechanocardiographicaphically. The data were analysed at 4 stages, that is, before administation, within 3 months, from 3 to 6 months and over 6 months after administration of Elastase.At each stage, the values of pulse wave velocity were 918±170, 784±186, 803±131, 781±102cm/sec, and volume elasticity, 2355±602, 1926± 557, 1984±462, 1950±343dyne/cm2 respectively, and the decrease of the indices was statistically significant (p<0.025-0.05). Total serum cholesterol and triglyceride were almost within normal limits at each stage (208±82, 261±112, 212±41, 186±40mg/dl; 150±89, 142±86, 172±102, 148± 99mg/dl, respectively).Total peripheral resistance was slightly decreased, consequently cardiac output was slightly increased. Blood pressure, heart rate, systolic time intervals, and the indices of cardiac function or cardiac contractility, that is, ET/PEP, SV/ET and A wave ratio of apexcardiogram, were not changed and remained within normal limits at all stages.We conclude that Elastase has a good influence upon the arteriosclerotic patients whose levels of total serum cholesterol and triglyceride are within normal limits as the agent did in the patients with hypercholesterinemia and hypertriglyceridemia, and the ameliorating effect on the pre-existing arteriosclerosis. This conclusion in clinical study is in agreement with many reports in animal experiments.