Abstract
The purpose of this study is to investigate the effect of Elateriospermum tapos aqueous extract supplementation on serum leptin of male offspring at weaning. A total of 30 female Sprague Dawley rats were assigned to two groups, where the control group (CG) consisted of six rats and the remaining rats had obesity-induced over five weeks with a high-fat diet pellet and cafeteria food. After five weeks, the obese group was further divided into four groups, a negative control group (NG), positive control group (PG) (orlistat 200 mg/kg), treatment 1 (TX1) (200 mg/kg BW of E. tapos seed) and treatment 2 (TX2) (200 mg/kg BW of E. tapos shell) for 6 weeks. After six weeks, all rats were mated and continued with their respective diet till weaning. One male pup from each dam culled at weaning (postnatal day 21 (PND21)). The results show that body weight in male offspring (M) from negative group dams (NG) was significantly heavier as compared to other pup groups. Total adipose tissue weight in MTX1 and MTX2 of the male offspring was also significantly lower compared to MNG. In mums, serum leptin of NG was significantly higher as compared to the CG group, whereas both treatment groups showed a significant reduction in serum leptin compared to the NG group. In pups, the MTX2 group showed a more substantial reduction in body weight and serum leptin compared to other pups from other mother’s groups. In conclusion, E. tapos aqueous extract supplementation has a greater effect on ameliorating maternal obesity effects on male offspring by lowering body weight, inhibit fat deposition, and reducing serum leptin.
Highlights
Maternal obesity is a contributor to childhood obesity because it does increase the number of children who are overweight or obese
A significant increase (p < 0.05) of body weight was observed among male pups from negative group dams (MNG) group pups compare to the MCG group
offspring positive group (MPG) group, which treat with Orlistat, shows a significant reduction of body weight compared to the negative control
Summary
Maternal obesity is a contributor to childhood obesity because it does increase the number of children who are overweight or obese. It increases the potential risk of children suffering from diseases including type 2 diabetes, cardiovascular diseases, asthma, dyslipidaemia, sleep apnea, non-alcoholic fatty liver disease, orthopaedic problems, depression and low self-esteem on their early childhood [1]. A lot of overweight children becoming adult obese and expose themselves to a greater risk of chronic diseases and disabilities. Diseases start earlier when a child is obese and often last until adulthood, with predictable implications of lost productivity, missed working days, healthcare costs increased, quality of life decreased, and lifespan is shortened [3]. Public awareness and knowledge on maternal obesity and its outcomes towards childhood obesity are yet low, and the public neglects it
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