Elaboration and Characterization of Macroporous Bioceramics using Polymeric Sponge Replication Method

Kamel Chaari,Khaled Bouzouita,Jamel Bouaziz

doi:10.5185/amlett.2020.111578

Abstract

Biomedical porous fluorapatite scaffolds were fabricated using an improved polymeric sponge replication method. The specific formulations and distinct processing techniques such as the mixture of water and dispersant (Sodium TriPolyPhosphate) as solvent, the multiple coatings with the desired viscosity of the Fap slurries were duplicated from Chaari et al. [11]. The heat treatment was conducted in two stages: a delicate stage of polymeric structure degradation at 290 0 C and then at 600 0 C followed by a sintering stage at 1000 0 C for three hours. The obtained porous Fap scaffolds had uniform porous structures with completely interconnected macropores of 850 μm. In addition, micropores of 4 μm were formed in the skeleton of the scaffold. Finally, the porous Fap scaffold with a porosity of 65 vol.% and a surface of 400 mm 2 had a compressive strength of 7 MPa.

Highlights

The application of calcium phosphate ceramics has become largely used in the biomedical field because of the close similarity of its structure and chemical composition to natural bone
The porous Fap scaffolds with an open and interconnected porous structure were obtained after optimizing the conditions of impregnation and sintering of the products
The optimized porous Fap scaffold with a porosity of 65 vol% had a compressive strength of 7 MPa

Summary

Introduction

The application of calcium phosphate ceramics has become largely used in the biomedical field because of the close similarity of its structure and chemical composition to natural bone. Ben Ayed, Bouaziz and Bouzouita [7,8,9], and Ben Ayed and Bouaziz [10] reported that Fap (Ca10(PO4)6F2: Fap) proved to have similar physicochemical properties to the natural bone. Chaari et al, [11] and Chaari, Bouaziz and Bouzouita [12] observed that this material showed a good thermal stability. Athanaela et al, [15] and Tredwin et al, [16], argued that the amount of the Fluoride ions Freleased directly affected the cell attachment and the proliferation, morphology and differentiation of osteoblast cells. Athanaela et al, [15] explained this by the fact that the fluorine ion itself enhances mineralization and crystallization

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Conclusion