Abstract
The use of recycled frying oil or deep frying oil (DFO) lead to increase in free fatty acid, trans fatty acid and free radical compound. It can cause non-alcoholic fatty liver disease (NAFLD). a chronic liver disease cause the risk for cirrhosis and heart cancer. However, there is no medicine for preventing the disease. The present study was conducted to investigate the turmeric reduces steatosis hepatocyte of male Wistar rat NAFLD model. The study used experimental randomize post-test only control group design. The 24 samples consist of four treatment groups. Group I (control): normal diet + DFO (10 μl/g/day on 6 times heating), Group II, III and IV: normal diet + DFO (10 μl/g/day on 6 times heating)+ turmeric Extract (100, 200, and 400 mg/kg/day) by given for 30 days through oral induction. The results of Kruskal-Wallis test showed a significant difference between the four treatment groups (P= 0.019) .The results of Mann-Whitney test showed significant difference in steatosis hepatocyte between the control group (P1) and treatment group(P3) the dose of 200 mg/kg BW. This suggests that a dose of 200 mg/kg BW is an effective dose in decreasing hepatocyte steatosis.
Highlights
PENDAHULUAN Masyarakat Indonesia masih sangat menyukai makanan yang berlemak atau digoreng di berbagai tingkat usia, dan dilaporkan bahwa penggunaan minyak goreng mencapai 2,5 juta ton pertahun atau 12 kg perorang per tahun (Novianti et al, 2017)
a chronic liver disease cause the risk for cirrhosis and heart cancer
there is no medicine for preventing the disease
Summary
Penggunaan minyak goreng berulang atau deep frying oil/DFO menyebabkan peningkatan asam lemak bebas, asam lemak trans dan komponen radikal bebas. Penggunaan minyak goreng berulang menyebabkan non-alcoholic fatty liver disease (NAFLD) yaitu penyakit hati kronis yang ditandai dengan sirosis hepatis dan kanker hati. Penelitian ini bertujuan mempelajari kemampuan rimpang kunyit menurunkan perlemakan hati (steatosis hepatosit) pada tikus Wistar jantan model NAFLD. Sebanyak 24 ekor tikus Wistar jantan model NAFLD dibagi menjadi empat kelompok perlakuan. Hasil uji Kruskal-Wallis menunjukkan adanya perbedaan bermakna antara keempat kelompok perlakuan (P=0,019). Hasil uji Mann-Whitney terdapat perbedaan bermakna pada steastosis hepatosit antara kelompok kontrol (P1) dengan kelompok perlakuan (P3) dosis 200 mg/kg BB. Hal ini menunjukkan bahwa dosis 200 mg/kg BB merupakan dosis yang efektif dalam menurunkan steatosis hepatosit
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
