Eight cases of congenital mesoblastic nephroma: clinical analysis and literature review

Abstract

Objective To heighten the realization of congenital mesoblastic nephroma (CMN) in children.Methods Eight cases of CMN treated in our hospital from Apr.2004 to Aug.2012 were included in this study.The age,gender,the location of pathologic change,clinical symptoms,pathological characteristics,imaging characteristics,therapeutic regimen and prognosis were analyzed retrospectively.Results Surgical treatment were performed in all eight patients,which including whole renal resection for 4 cases,tumor resection for 3 cases and half nephrectomy for 1 case.Pathological classification revealed classic CMN in 2 cases and cellular CMN in 6 cases.Two cases received preoperative chemotherapy but no response while 3 cases received postoperative chemotherapy.Three cases of classic CMN were demonstrated as solid mass while 5 cases of cellular CMN were demonstrated as focal areas of cystic/necrosis/calcification by ultrasound and CT scan.The mean follow-up time was 14.6 months,the longest was 36 months.Two cases lost to follow-up,tumor recurrence occurred in 1 case at the eighth month after operation and surgical resection performed again.Six patients survived uneventfully.Conclusions CMN is a kind of rare benign tumor which comes from mesoderm,differential diagnosis should be made with Wilms'tumor; imaging characteristics have part correlation with pathologic characteristics; surgery is the main treatment,preoperative chemotherapy is not sensitive,the effect of postoperative chemotherapy need further study,the prognosis is fairly good. Key words: Nephroma,mesoblastic; Urologic surgical procedures; Drug therapy,combination