Abstract

A series of eight cases of AFP-producing gastric cancer experienced at the hospital in a recent 5-year period were clinicopathologically studied. Preoperative AFP levels in the subjects ranged from 50.31 ng/ml to 144, 5100 ng/ml. Six of these eight cases were of advanced cancer, and five out of the six cases had a Bormann type 3 carcinoma. It was histopathologically peculiar that seven cases had ly3 and all of them had severe lymphatic invasion. Histologically, four cases had porlmainly, and hepatocyte like tumor cells were confirmed in five cases. As to lymph node metastases, there were no case of n0, three cases of n1, and remaining cases of n2 or more; all cases had metastatic foci. Five of the eight patients had hepatic metastasis and died within one year. It is suggested that AFP-producing gastric cancers are liable to metastasize to the liver and the hepatic metastasis itsefl is an important factor determining the prognosis of the patient. From the above, it is indicate that AFP-producing gastric tumors have a biologically potent malignancy and need treatments including extended lymph nodes dissection and indwelling of a reservoir for the liver metastasis in an early stage.

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