Abstract
Eicosapentanoic acid (EPA), an omega‐3 polyunsaturated fatty acids (ω‐3 PUFAs), protects against photodamage and photocarcinogenesis in mammals. Water movement across the plasma membrane can occur via two pathways: by diffusion through the lipid bilayer and by membrane inserted water channels (aquaporins; AQPs). At least 13 subtypes, denoted AQP0‐AQP12, have so far been identified in mammalian cells. AQP3 is a water/glycerol transporting protein in basal layer keratinocytes of epidermis in normal skin. We have investigated the effects of EPA on AQP3 expression and the effects of EPA on ultraviolet (UV)‐induced AQP3 down˗regulation in cultured human skin keratinocytes. EPA treatment increased AQP3 gene and protein expression in human epidermal keratinocytes (HaCaT). Using a specific inhibitor, we observed that the effect of EPA on AQP3 expression was mediated by ERK activation. UV induced AQP3 down‐regulation in HaCaT cells. EPA treatment attenuated UV‐induced AQP3 loss and cell death. Collectively, the present results show that EPA increased AQP3 expression and protected against photodamage of UV through the induction of AQP3 expression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
