Abstract
Background and Aims : Lipid oxidation leads to endothelial dysfunction and promotes foam cell formation during atherogenesis. Treatment with icosapent ethyl, a formulation of highly-purified omega-3 fatty acid (O3FA) EPA, reduced cardiovascular (CV) events in REDUCE-IT unlike trials using DHA-containing formulations in statin-treated patients. We compared the effects of EPA and DHA on lipid oxidation in membranes in combination with high-intensity statins.
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