Abstract
The effects of elevated glucose and Eicosapentaenoic acid (EPA, 20:5) on myoinositol uptake in human aortic smooth muscle cells (HASMC) were evaluated. Myo-inositol incorporation into HASMC was dependent on an active transport system via Na +−K + ATPase activity based on the results with Na + deprivation and Ouabain (5 mM). Although glucose (27.5, 55 mM) inhibited 2-[ 3H] myo-inositol uptake, the addition of EPA (3×10 4 M) prevented glucose-mediated inhibition. In addition, EPA potentiated Na +−K + ATPase activity of HASMC. Since EPA decrease glucose-mediated inhibition of myo-inositol uptake, this agent might ameliorate aortic smooth muscle cell function associated with diabetes.
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