Abstract
Primary cultures of astrocytes and meningeal cells derived from neonatal rat brain synthesize and release thromboxane A 2 and prostacyclin, respectively. Exogenously supplied arachidonic acid and the calcium ionophore, A23187, promote the release of eicosanoids; these effects are blocked by indomethacin and the calcium chelator, ethyleneglycoltetraacetic acid. The finding that astrocytes synthesize and release thromboxane A 2 is discussed in the light of our recent findings of receptor-linked membrane phospholipid turnover in these cells.
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