Abstract
Functional neuroimaging studies have shown hyperresponsiveness of cortical areas to visual stimuli in migraine patients with aura outside of attacks. This may be a key feature in the initiation of aura episodes and possibly also migraine headache attacks. It is unknown if cortical dysfunction is present at rest, i.e. in the absence of any external stimuli. Functional magnetic resonance imaging (fMRI) is a powerful technique for evaluating resting-state functional connectivity, i.e. coherence of brain activity across cerebral areas.
Highlights
Functional neuroimaging studies have shown hyperresponsiveness of cortical areas to visual stimuli in migraine patients with aura outside of attacks
We found no differences of functional connectivity between patients and controls
The previously reported increased cortical hyperresponsivity in the interictal phase of migraine with aura is unlikely to be caused by abnormalities of intrinsic brain connectivity
Summary
Functional neuroimaging studies have shown hyperresponsiveness of cortical areas to visual stimuli in migraine patients with aura outside of attacks. No abnormalities of intrinsic brain connectivity during the interictal phase of migraine with aura A Hougaard1*, FM Amin1, S Magon2, T Sprenger2, E Rostrup3, M Ashina1
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