Abstract
The neuropathology leading to migraine pain has centered on an either a vascular or neuronal origin. Sildenafil, a specific inhibitor of phosphodiesterase 5 (PDE5), was the first compound to induce migraine-like headache in a human headache model without a concomitant artery dilatation.
Highlights
The neuropathology leading to migraine pain has centered on an either a vascular or neuronal origin
Hydrolysis of cyclic AMP was in contrast to cGMP, influenced by both sildenafil and cilostazol, suggesting sildenafil, cilostazol and calcitonin gene related peptide (CGRP) may work through a common cAMP pathway resulting in migraine pain
We further addressed a possible cross-talk with a key molecule in migraine pain signaling, calcitonin gene related peptide (CGRP), by investigating cellular co-localization
Summary
The enzymes phosphodiesterase 3 and 5 express activity in the trigeminal ganglion and co-localize with calcitonin gene-related peptide. From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark. From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark. 18-21 September 2014
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