Abstract
Migraine with typical aura (MTA) and migraine without aura (MO) are common neurological disorders with complex inheritance. Recent efforts have identified 12 independent loci at which single nucleotide polymorphisms (SNPs) have shown to confer risk of migraine (Antilla V. Nat.Genet 2013). The objective of this study was to investigate whether these SNPs could be replicated in a Danish clinic based migraine sample and to test if the risk-alleles are associated with severe migraine traits.
Highlights
Introduction and aimMigraine with typical aura (MTA) and migraine without aura (MO) are common neurological disorders with complex inheritance
The objective of this study was to investigate whether these SNPs could be replicated in a Danish clinic based migraine sample and to test if the risk-alleles are associated with severe migraine traits
Semi-structured migraine interviews based on a validated questionnaire, blood samples and genotyping were performed on 1806 unrelated migraineurs from the Danish Headache Center, Glostrup Hospital
Summary
Migraine with typical aura (MTA) and migraine without aura (MO) are common neurological disorders with complex inheritance. Recent efforts have identified 12 independent loci at which single nucleotide polymorphisms (SNPs) have shown to confer risk of migraine The objective of this study was to investigate whether these SNPs could be replicated in a Danish clinic based migraine sample and to test if the risk-alleles are associated with severe migraine traits
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