Abstract
Infusion of the nitric oxide (NO) donor, glyceryl trinitrate (GTN), provokes a migraine-like attack in migraineurs and cFos up-regulation in rat trigeminal nucleus caudalis. We studied the level of dura mast cell degranulation after infusion of GTN in awake, freely moving rats and hypothesized that the degranulation is secondary to NO.
Highlights
Infusion of the nitric oxide (NO) donor, glyceryl trinitrate (GTN), provokes a migraine-like attack in migraineurs and cFos up-regulation in rat trigeminal nucleus caudalis
Glyceryl trinitrate provoked mast cell degranulation is secondary to the release of nitric oxide in vivo
We studied the level of dura mast cell degranulation after infusion of GTN in awake, freely moving rats and hypothesized that the degranulation is secondary to NO
Summary
Glyceryl trinitrate provoked mast cell degranulation is secondary to the release of nitric oxide in vivo. S Hougaard Pedersen1*, R Ramachandran, DV Amrutkar, S Petersen, J Olesen, I Jansen-Olesen. From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark. From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark. 18-21 September 2014
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