Abstract
To examine both migraine and pulmonary hypertension (PH) we developed a hypoxic mouse model. Under hypoxic conditions (four weeks at 10% O2) mice develop typical symptoms of PH, characterized by an increased muscularization of arterial blood vessels in the lung. The vessel remodeling can be prevented by the chronic application of 5-HT2B receptor antagonists. We found that hypoxic mice also develop increased sensitivity towards the 5-HT2 receptor agonist meta-Chlorophenylpiperazine (mCPP). In contrast to the control group (normoxic mice kept at 20% O2) at low doses of 1 µg / kg body weight, mCPP triggers plasma protein extravasation (PPE) in the dura mater in hypoxic mice. Dural PPE is a quantifiable indicator of migraine-like events in animal models.
Highlights
To examine both migraine and pulmonary hypertension (PH) we developed a hypoxic mouse model
We found that hypoxic mice develop increased sensitivity towards the 5-HT2 receptor agonist meta-Chlorophenylpiperazine
In contrast to the control group at low doses of 1 μg / kg body weight, mCPP triggers plasma protein extravasation (PPE) in the dura mater in hypoxic mice
Summary
To examine both migraine and pulmonary hypertension (PH) we developed a hypoxic mouse model. Quantitative histological examinations of inter- and intraindividual differences in the dural vasculature of the mouse From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark.
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