Abstract
Spreading depression (SD) is known by transient loss of spontaneous and evoked neuronal activity and changes in ionic, metabolic and hemodynamic characteristics of the brain. It has been shown that repetitive SD produced memory deficits in juvenile rats. Furthermore, the role of Ca2+channels on induction and propagation of SD was investigated by several scientists. The aim of the present study was to study the role of a Ca2+channel-blocker, nifedipine, on memory deficits induced by repetitive SD.
Highlights
Spreading depression (SD) is known by transient loss of spontaneous and evoked neuronal activity and changes in ionic, metabolic and hemodynamic characteristics of the brain
It has been shown that repetitive SD produced memory deficits in juvenile rats
The aim of the present study was to study the role of a Ca2+channel-blocker, nifedipine, on memory deficits induced by repetitive SD
Summary
Spreading depression (SD) is known by transient loss of spontaneous and evoked neuronal activity and changes in ionic, metabolic and hemodynamic characteristics of the brain. Effect of nifedipine on memory impairment induced by repetitive spreading depression From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark.
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