Ehanol extract from Achantus Ilicifolius L. leaves as anti-inflammatory ulcers in Mus musculus L.

Abstract

This study aims to determine the effective concentration of Acanthus ilicifolius L. leaves to treat the number of ulcers and gastric ulcer severity in white mice (Mus musculus L.) which were induced 500 ppm of aspirin. The approach used was quantitative by using a completely randomized design (CRD) factorial pattern with two factors. The results of statistical analysis of the number of ulcers for factor A (source) show the value of Fcount>Ftable = 15>3.16, while factor B (concentration) shows the value of Fcount>Ftable = 64> 2.38 at the test level α 0.05. While the results of statistical analysis of factor A ulcer severity (Source) shows the value of Fcount > Ftable = 4 > 3.16 and factor B (concentration) Fcount > Ftable = 38 > 2.38 at the test level α 0.05. The highest percentage of treatment was at the concentration of P2 (250,000 ppm) and P3 (500,000 ppm) at 17%. The ability of gastric ulcer healing in mice is because the parts of the Achantus ilicifolius L contain several phytochemical compounds including flavonoids, saponins, alkaloids, phenolics, and terpenoids. Therefore, it can be concluded that the Achantus ilicifolius L leaves with a concentration of 250,000 ppm are effective in treating the number of gastric ulcer and ulcer severity in mice.