Abstract
The purpose of this study was to investigate the incidence and clinical significance of alterations in EGFR, IGF1R and the cell signaling pathway activities induced by them, as well as EGR1 expression in resected non-small cell lung cancer (NSCLC). The protein expressions of biomarker were evaluated by Western blotting in tissues from 19 surgically resected NSCLCs. High expressions of EGR1, EGFR and IGF1R were detected in more than 30% tumor tissues. High expressions of pErk and pAkt were detected in more than 50% paracancer tissues. There were significant correlations between the NSCLC target factors detected (p<0.05). Alterations of protein expressions of target factor detected in NSCLC were significantly associated with alterations in pathological subtype, differentiation, pathological stage, and smoking history. Positive EGR1 might be associated with good survival, while positive pErk might be associated with poor prognosis.
Highlights
EGFR and IGF1R play important roles in the tumorigenesis and development of lung cancers, and they have preferred therapeutic molecular targets
The relationship between IGF1R expression and prognosis is not determined (Nakagawa et al, 2012; Kim et al, 2014; Kim et al, 2012), and EGR1 expression seems to be a fine predictor in non-small cell lung cancer (NSCLC) patients (Ferraro et al, 2005)
Study has found that both EGFR gene copy number and its protein expression are over expression in NSCLC, and there is apparent correlation between them (Hirsch et al, 2003)
Summary
EGFR and IGF1R play important roles in the tumorigenesis and development of lung cancers, and they have preferred therapeutic molecular targets. EGR1 overexpression is detected in the adenocarcinoma cells with K-RAS mutation-positive and EGFR mutation-positive (Ferraro et al, 2005). Recent study suggests that EGR1 is possibly a signaling crosstalk between the Erk pathway and Akt pathway. The relationship between IGF1R expression and prognosis is not determined (Nakagawa et al, 2012; Kim et al, 2014; Kim et al, 2012), and EGR1 expression seems to be a fine predictor in non-small cell lung cancer (NSCLC) patients (Ferraro et al, 2005). The present study intends to investigate the activated state of both the EGFR and IGF1R signaling pathways in NSCLC, and the relationships among EGR1, EGFR, IGF1R and clinical data
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
