Abstract
The T-cell receptor on the surface of T cells requires antigen recognition to function. Structural studies reveal that its predecessor, the pre-T-cell receptor, is much more independent. See Letter p.844 The pre-T-cell antigen receptor (pre-TCR) plays an important part in adaptive immunity by mediating early T-cell development and differentiation. The structure of pre-TCR and the pre-TCR dimer have now been determined, revealing how the head-to-tail dimeric arrangement allows the interaction of the invariant α (pre-Tα) domain with any variable (V) β domain, and provides the basis for ligand-independent signalling.
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