Egg Yolk Phospholipids Modulate Microbial Imbalance in the Intestinal Tract of Rats on a High‐Fructose Diet

Abstract

AbstractHigh‐fructose diet (HFD), a cause of excessive obesity and destruction of the structure of the intestinal ecosystem, has become a common eating habit. This study aims to explore the effect and mechanism of egg yolk phospholipids (EPLs) on improving obesity, intestinal short‐chain fatty acids (SCFAs), and intestinal bacterial structure in rats induced by HFD. Results indicate that EPLs exhibit better effects on anti‐obesity than those of soy phospholipids (SPLs). EPLs increase the reduction of SCFAs caused by HFD, increased acetic acid, propionic acid, isobutyric acid, and total SCFAs, which effectively regulate the environment of intestinal microbial metabolism. Moreover, EPLs decrease Firmicutes/Bacteroides ratio (F/B) and the relative abundance of Streptomyces, Arthrobacter, and Desulfovibrio, and increase the relative abundance of Mucilaginibacter and Cellulomonas. These results suggest that EPLs have a potential modulating effect on intestinal disorders caused by HFD.Practical Applications: The results of this study illustrate that phospholipids are a promising supplement to alleviate the intestinal flora disorder caused by a high‐fructose diet, and its protective effect is mainly to regulate the composition of intestinal short‐chain fatty acids.