EGFR mutations in sinonasal squamous tumors: oncogenic and therapeutic implications.

Aaron M Udage,Jonathan B Mchugh,Noah A Brown,Kojo S.J Elenitoba-Johnson

doi:10.18632/oncoscience.268

Abstract

EGFR mutations in sinonasal squamous tumors: oncogenic and therapeutic implications.

Highlights

The etiology of sinonasal tumors is a topic of current debate [1]
In cell lines derived from inverted sinonasal papillomas (ISP)-associated Sinonasal squamous cell carcinoma (SNSCC), EGFR mutations were shown to result in activation of EGFR as well as downstream constituents of the MAPK and
These functional studies and the high frequency of EGFR mutations suggest that dysregulated EGFR signaling plays a central role in the oncogenesis of ISP and associated SNSCC – a finding that is an apparent departure from prior paradigms involving human papillomavirus (HPV) infection [1]

Summary

Introduction

The etiology of sinonasal tumors is a topic of current debate [1]. While ESP is associated with infection by low-risk human papillomavirus (HPV) in 55% - 65% [1, 3], most studies have demonstrated significantly lower HPV detections rates for ISP [3, 4]. The oncogenic role of EGFR mutations was supported in this study by functional experiments. In cell lines derived from ISP-associated SNSCC, EGFR mutations were shown to result in activation of EGFR as well as downstream constituents of the MAPK and

Results

Conclusion