Abstract
Objectives This study evaluated the relationships between estimated glomerular filtration rate (eGFR) and carotid atherosclerosis, peripheral arterial disease (PAD), arterial stiffness, and left ventricular hypertrophy, independent of albuminuria. Methods The study population consisted of 6694 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2009. The common carotid artery intima-media thickness (CCA-IMT), carotid plaque, ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and left ventricular mass index (LVMI) of each subjects was assessed. Results After adjustment for risk factors and albumin–creatinine ratio (ACR), kidney dysfunction (eGFR = 30–44 ml/min per 1.73 m 2) was significantly associated with carotid plaque presence (odds ratio [OR], 1.75; 95% confidence interval [CI], 1.21–2.53) and PAD (OR, 2.64; 95% CI, 1.51–4.62) compared to normal kidney function (eGFR ≥ 60 ml/min per 1.73 m 2). Similarly, mean LVMI and baPWV differed significantly according to eGFR after adjustment for other risk factors and ACR; in contrast, no significant difference was observed for CCA-IMT. Conclusions Independent of albuminuria, eGFR is associated with carotid plaque, PAD, baPWV, and LVMI but not with CCA-IMT in Koreans aged 50 years and older.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
