Abstract

Background: The EGF-based vaccine, commercially known as CIMAvax-EGF®, consists of a chemical conjugate of the epidermal growth factor (EGF) with the P64 protein derived from the Meningitis B bacteria and the Montanide ISA 51, as adjuvant. The vaccine induces antibodies against EGF that results in EGF castration. CIMAvax-EGF has been demonstrated to be safe and immunogenic in advanced NSCLC patients and more recently in non-invasive bladder cancer patients.

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