Abstract
1. 1. The efflux of chloride (using 36Cl) from lactating rat mammary tissue slices has been investigated. 2. 2. Chloride efflux was found to be temperature dependent; lowering the temperature of the incubation medium reduced the fractional efflux. 3. 3. The stilbene derivatives DIDS was without effect on the fractional release of Cl when studied at 20°C. However, DIDS was found to attenuate the increase in efflux found upon transferring the tissue from a medium maintained at 4°C to one at 20°C. 4. 4. The loop-diuretic furosemide, also reduced the temperature-sensitive portion of Cl efflux. 5. 5. Chloride efflux was transiently increased when tissue slices were transferred from a medium containing gluconate as the principal anion to one containing Cl. 6. 6. The results appear to confirm that mammary Cl transport is mediated via anion exchange and via (Na + K + Cl) cotransport.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Comparative Biochemistry and Physiology Part A: Physiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
