Abstract
Efficient intravascular gene delivery to the endothelium in defined vascular beds pertinent to pathological states has been a long-pursued goal for many gene therapy applications. Clear advantages include the minimally invasive route of delivery and the ability to target distal sites in the body that are relatively inaccessible surgically. Such targets are diverse and include angiogenic endothelium in cancer, the vasculature of defined organs such as the lung, and microvascular endothelium in regions of poor blood flow.
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