Abstract
Front Cover: Polypiperazines are hydrophilic pH-sensitive polymers reaching high transfection efficiency and guaranteeing good biocompatibility. They are almost charge-neutral under physiological conditions avoiding unintended side effects, while the isopropyl-modified polypiperazine outperforms the commercial linear PEI at low N/P ratios. qPCR revealed that pDNA can still be amplified while complexed with piperazine-based polymers, providing a promising platform for effective polymeric gene delivery systems. This is reported by Anja Traeger, Johannes C. Brendel, and co-workers in article number 2200517.
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