Abstract
The reaction of a sulfonamide moiety with HBTU ( O-(1 H-benzotriazol-1-yl)- N, N, N′, N′-tetramethyluronium hexafluorophosphate) during amide coupling, leading to the formation of tetramethylsulfonylguanidines, is described. Optimised conditions showed that HBTU was as a convenient agent for the synthesis of tetramethylsulfonylguanidines, in basic conditions. A panel of diverse sulfonamides was used to demonstrate the scope of this procedure.
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