Efficient synthesis of pyrrolizidine and indolizidine derivatives using nickel-catalyzed cyclization of 1,3-diene and aldehyde: Formal total synthesis of (−)-Elaeokanine C

Abstract

Pyrrolizidine and indolizidine skeletons were successfully constructed by nickel-catalyzed cyclization of 1,3-diene and aldehyde in a chain. A formal total synthesis of an Elaeocarpus alkaloid, (−)-Elaeokanine C, in the naturally occurring form was achieved using this cyclization.