Abstract
An efficient method for the synthesis of nucleoside phosphoramidates prodrugs ( 6a– f) has been developed that employs a simple protection/deprotection sequence of the nucleoside with benzyloxycarbonyl (Cbz). The coupling reaction of Cbz-protected derivatives ( 5a– f) with phenyl-(ethoxy- l-alaninyl)-phosphorochloridate ( 7), followed by Cbz group removal by hydrogenolysis provided the phenyl phosphoramidate ProTides ( 6a– f) in excellent overall yields.
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