Efficient synthesis of novel 1,2,4-triazole fused acyclic and 21–28 membered macrocyclic and/or lariat macrocyclic oxaazathia crown compounds with potential antimicrobial activity

Abstract

Versatile simple efficient routes with good to excellent yields towards different functionalized 1,ω-bis(1,2,4-triazoles), 21–28 membered 1,2,4-triazole fused macrocyclic and/or lariat macrocyclic oxaazathia crown Schiff bases and/or amines have been investigated. Antimicrobial screening of some selected compounds revealed different inhibitory effects against Aspergillus fumigatus RCMB 002008 ( 1), Penicillium italicum RCMB 001018 ( 1), Syncephalastrum racemosum RCMB 016001 Candida albicans RCMB 005003, Staphylococcus aureus RCMB 106- 001 ( 1), Pseudomonas aeruginosa RCMB 102- 002, Bacillus subtilis RCMB 101- 001 and Escherichia coli RCMB 103- 001.