Efficient synthesis of N- and O-linked glycopeptides using acid-labile Boc groups for the protection of carbohydrate moieties

Abstract

Development of a synthetic method for the preparation of homogeneous glycopeptides and glycoproteins is important for the elucidation of their structures and functions. Here, we report on the concise and facile synthesis of glycopeptides using Boc groups for the protection of carbohydrate hydroxyl groups. This method enables us to remove the protecting groups from peptide and carbohydrate moieties in a single-step process without undesirable any side reaction.