Efficient synthesis of multi-responsive MSN sensitive to ROS, pH and temperature with significant anticancer effects

Abstract

In order to overcome the low drug loading capacity of mesoporous silica nanoparticles (MSN) and the toxic side effects caused by premature drug release, in this study, high-surface-area MSN were efficiently synthesized via the Flash Nanoprecipitation (FNP). Through layered structural modifications, nanoparticles were created with multi-responsive characteristics toward reactive oxygen species (ROS), pH, and temperature. These nanoparticles improved the loading efficiency for doxorubicin (DOX), showcasing sensitivity to the tumor microenvironment and enabling controlled drug release. Additionally, these nanoparticles showed good biocompatibility and significant anticancer effects. Our findings provide a promising avenue for improving the effectiveness of cancer treatment.