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Abstract
Piperazine dione derivatives (1a–j) on condensation with 2,6-pyridine dicarboxylic acid (2x), 3,5-pyridine dicarboxylic acid (2y) and 2,5-thiophene dicarboxylic acid (2z) gave corresponding heterocyclic compounds 3ax–3jz in excellent yields. All the newly synthesized compounds were fully characterized by spectroscopic means and elemental analysis. On screening for anti-inflammatory and for in vitro anticancer activity, compounds 3bx, 3cx, 3dx, and 3ex exhibited good anti-inflammatory activity, whereas compounds 3ay, 3az, 3cz, 3dx, 3ez, 3fx, 3gx, and 3hz exhibited good anticancer activity.
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