Abstract
AbstractA new synthetic route utilizing biomass‐derived furans as a starting material for the production of bis(5‐arylfuran‐2‐yl)methane scaffolds was developed. Decarboxylative cross‐coupling of 5‐hydroxymethylfuroic acid (HMFA) was studied in detail with overall good yields. Acid‐catalyzed self‐condensation was optimized to produce the target structures in excellent yields. Overall, this report introduces a new expedient synthesis to obtain bis(furyl) methane scaffolds that avoids the use of protecting groups and highlights the utilization of renewable carbon sources as starting materials.
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