Abstract
An efficient and straightforward synthesis of beraprost sodium has been developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Horner-Wadsworth-Emmons reaction as key steps. The structures of key intermediate and target compound were confirmed by 1H NMR, 13C NMR and MS. The purity of beraprost sodium identified by high performance liquid chromatography(HPLC) was identical to that of Japanese Pharmacopoeia(16th). This development will be used for the industrial synthesis of beraprost sodium.
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