Abstract

AbstractA series of new pyrazolo[1,5‐a]pyrimidine 4–15 derivatives were synthesized starting from 3,5‐diaminopyrazole derivatives 3 a,b as precursor using a simple, efficient procedure, and screened for their in‐vitro antimicrobial activities. All the synthesized compounds were fully characterized by IR, 1HNMR, 13CNMR, MS spectral data, and elemental analysis. Among the investigated against the antimicrobial activity, compounds 4 b, 4 d, 4 e, 8 b, 9 and 12 showed the best activity. The remaining compounds were found to have weak activity against gram‐positive and gram‐negative.

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