Abstract
Sophisticated mechanically interlocked molecules (MIMs) with interesting structures, properties and applications have attracted great interest in the field of supramolecular chemistry. We herein report a highly efficient self-assembly of heterometallic triangular necklace 1 containing Cu and Pt metals with strong antibacterial activity. Single-crystal X-ray analysis shows that the finely arranged triangular necklace 1 has two racemic enantiomers in its solid state with intriguing packing motif. The superior antibacterial activity of necklace 1 against both standard and clinically drug-resistant pathogens implies that the presence of Cu(I) center and platinum(II) significantly enhance the bacterium-binding/damaging activity, which is mainly attributed to the highly positively charged nature, the possible synergistic effect of heterometals in the necklace, and the improved stability in culture media. This work clearly discloses the structure-property relationships that the existence of two different metal centers not only facilitates successful construction of heterometallic triangular necklace but also endows it with superior nuclease properties and antibacterial activities.
Highlights
Sophisticated mechanically interlocked molecules (MIMs) with interesting structures, properties and applications have attracted great interest in the field of supramolecular chemistry
The early research of molecular necklace could be traced back to the work reported by Sauvage et al, who generated a mixture of molecular necklaces by accident in a very low yield and characterized their structures by using electrospray ionization mass spectrometry (ESI-MS)[29]
Pseudorotaxane deposition numbers CCDC 1889123 (D1) consisting of two functional ligands of pyridine and phenanthroline was synthesized from the starting materials M1 and D2 according to a literature method[54] with minor modifications (Supplementary Fig. 1)
Summary
Sophisticated mechanically interlocked molecules (MIMs) with interesting structures, properties and applications have attracted great interest in the field of supramolecular chemistry. The coordination-driven self-assembly of the positively charged metallosupramolecular complexes just provides a powerful platform to enhance the electric charges for severely disruption of the targeted DNA/cell wall/plasma membrane, and to improve the stability for prolonging the interaction time between the necklaces and the bacterial cells.
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