Abstract
Efficient recovery of of 1-CA from the bioreaction mixture was investigated using an ion-exchange (IEX) process. Among seven IEX resins examined, the anion resin 201×7 exhibited the highest adsorption capacity for 1-CA. The Freundlich model has the better description for 1-CA adsorption equilibrium than the Langmuir model. The adsorption kinetics showed that the pseudo-second order model was fitted very well. Dynamic adsorption and desorption experiments have been carried out in a fixed bed column to obtain optimal parameters for the recovery of 1-CA from the bioreaction mixture. Under the optimized conditions, 1-CA was recovered in yield of 91.3% with > 99% HPLC purity.
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