Efficient, Rapid and One Pot Synthesis of 2-substituted Benzimidazoles Using the NaOH/I2 System as an Oxidant Under Mild Conditions

Abstract

A one-pot efficient synthesis of benzimidazole derivatives has been achieved from aryl aldehydes and o-phenylenediamine in the presence of the NaOH/I2 system at room temperature in acetonitrile. The simplicity of the procedure and work-up, larger scale synthesis, high yields and short reaction times are the advantages of this method.