Efficient radical domino approach to β-aminoalcohols from arylamines and alcohols triggered by Ti(III)/ t-BuOOH

Raffaele Spaccini,Alessandra Ghilardi,Nadia Pastori,Angelo Clerici,Carlo Punta,Ombretta Porta

doi:10.1016/j.tet.2010.01.039

Efficient radical domino approach to β-aminoalcohols from arylamines and alcohols triggered by Ti(III)/ t-BuOOH

Raffaele Spaccini, Alessandra Ghilardi + Show 4 more

https://doi.org/10.1016/j.tet.2010.01.039

Copy DOI

Journal: Tetrahedron	Publication Date: Jan 18, 2010
Citations: 13

Affiliation: Politecnico di Milano

#Free-radical Mechanism #Good Yields + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

We report that an aqueous Ti(III)/ t-BuOOH system promotes the efficient domino radical reaction of arylamines with alcohol cosolvents leading to β-aminoalcohols in good yields, in less than ten minutes at room temperature. The free-radical mechanism according to which the amine reacts with two molecules of the alcohol is discussed.

Full Text