Abstract
Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.
Highlights
Cervical carcinoma has become the fourth most prevalent malignant cancer in women, affecting nearly 600, 000 women worldwide annually (Koh et al, 2019; Arbyn et al, 2020)
Mesoporous silica nanoparticles (MSNs) were prepared by a sol–gel method, in which the surfactant CTAC was used as a template and TEOS was chosen as a silica precursor
The transmission electron microscopy (TEM) images showed that MSNs, MI, and coated MSNs@ICG (CMI) display spherical shape with a diameter of approximately 50 nm (Figure 2A)
Summary
Cervical carcinoma has become the fourth most prevalent malignant cancer in women, affecting nearly 600, 000 women worldwide annually (Koh et al, 2019; Arbyn et al, 2020). Cervical carcinoma is the fourth leading cause of cancer-related death in women, killing approximately 300,000 women globally every year (Koh et al, 2019; Arbyn et al, 2020). The near-infrared (NIR) fluorescence used as PA probes for PA imaging could obtain a strong PA signal due to high photo penetration depth and low background autofluorescence, but its tumor-targeting specificity should be improved (Meng et al, 2018; Reinhardt and Chan, 2018; Sun et al, 2019b). The tumor-targeting specificity remains a challenge for the PA imaging of cancer
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