Abstract
This Letter reports new and efficient synthetic approaches for biologically interesting cannabinoid analogues. The key strategies involve ethylenediamine diacetate/triethylamine-catalyzed cyclization. As an application of this methodology, one-step synthesis of biologically active natural (−)-hexahydrocannabinol and its unnatural enantiomer (+)-hexahydrocannabinol was carried out.
Published Version
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