Efficient Multigram Syntheses of Air-Stable, Chiral Primary Phosphine Ligand Precursors via Palladium-Catalyzed Phosphonylation of Aryltriflates

Abstract

Air-stable, chiral primary phosphines have been synthesized on a multigram scale. The key synthetic step is an optimized palladium-catalyzed phosphonylation reaction of aryltriflates, which opens up a valuable synthetic route to a chiral scaffold that is easily derivatized into novel phosphines.