Abstract
AbstractIn the presence of imidazole hydrochloride, an efficient one‐pot three‐component synthesis of Biginelli reaction of aromatic aldehydes and aliphatic aldehydes, ethyl acetoacetate, and thiourea/urea was developed with good yields of dihydropyrimidines. High yields (80–95 %), mild reaction conditions, an easy work‐up process, a fast reaction time and simple operations are all significant features of the reaction. A total of 15 dihydropyrimidines were synthesized and out of which 12 compounds were evaluated for their anti‐cancer activity against cancer cell lines viz.A549, HT29, HepG2. Most of the synthesized compounds showed moderate to good anti‐cancer activity (IC50=150>200 μM).
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