Efficient Method for the Synthesis of α,α′-Bis(arylmethylidene) Cycloalkanones Catalyzed by Bromodimethylsulfonium Bromide

Abstract

Bromodimethylsulfonium bromide (BDMS)–catalyzed crossed aldol condensation between aromatic aldehydes and ketones is reported to access α,α′-bis(arylmethylidene) cycloalkanones at room temperature in good yields within 3–10 min. The salient features of this method are the simplicity of the procedure, the ready accessibility of the catalyst, and greater yields in relatively short reaction times. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]